The evolution of the cancer niche during multistage carcinogenesis

The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistag...

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Bibliographic Details
Published inNature reviews. Cancer Vol. 13; no. 7; pp. 511 - 518
Main Authors Barcellos-Hoff, Mary Helen, Lyden, David, Wang, Timothy C
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.07.2013
Subjects
Cancer
Carcinogenesis
Genetic aspects
Humans
Neoplasms - etiology
Neoplasms - pathology
Neoplasms - therapy
Risk factors
Stromal Cells - physiology
Tumor Microenvironment - physiology
United States
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Summary:The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1474-175X
1474-1768
DOI:10.1038/nrc3536