Species Distribution and Virulence Factors of Candida spp. Isolated from the Oral Cavity of Kidney Transplant Recipients in Brazil

• Published in: Mycopathologia (1975) Vol. 175; no. 3-4; pp. 255 - 263
• Main Authors: Chaves, Guilherme Maranhão, Diniz, Mariana Guimarães, da Silva-Rocha, Walicyranison Plinio, de Souza, Luanda Bárbara Ferreira Canário, Gondim, Libia Augusta Maciel, Ferreira, Maria Angela Fernandes, Svidzinski, Terezinha Inez Estivalet, Milan, Eveline Pipolo
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2013; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Analysis; Biofilms - growth & development; Biomedical and Life Sciences; Brazil; Candida - classification; Candida - genetics; Candida - isolation & purification; Candida - physiology; Candida albicans; Candida dubliniensis; Candida glabrata; Candida tropicalis; Carrier State - microbiology; Cell Adhesion; Child; Epithelial Cells - microbiology; Eukaryotic Microbiology; Female; Humans; Infections; Kidney Transplantation; Kidney transplants; Kidneys; Life Sciences; Male; Medical Microbiology; Microbial Ecology; Microbiology; Middle Aged; Mouth - microbiology; Mycoses; Organ transplant recipients; Peptide Hydrolases - metabolism; Plant Sciences; Prevalence; Transplantation; Virulence; Virulence (Microbiology); Virulence Factors - metabolism; Yeast; Young Adult; Brazil; Rio Grande do Norte Brazil; spp; Kidney transplant recipients; Virulence factors; Epidemiology
• ISSN: 0301-486X; 1573-0832
• DOI: 10.1007/s11046-013-9640-5

Although yeasts belonging to the genus Candida are frequently seen as commensals in the oral cavity, they possess virulence attributes that contribute for pathogenicity. The aims of the present study were to study the prevalence of Candida spp. isolated from the oral cavity of renal transplant recipients and to analyze strains virulence factors. We isolated a total of 70 Candida strains from 111 transplant recipients, and Candida albicans was the most prevalent species (82.86 %). Oral candidiasis was diagnosed in 14.4 % kidney transplant patients, while 11 isolates (15.7 %) corresponded to non- Candida albicans Candida (NCAC) species. C. albicans adhered to a higher extension than NCAC strains. Some isolates of Candida tropicalis were markedly adherent to human buccal epithelial cells and highly biofilm-forming strains. Regarding proteinase activity, Candida orthopsilosis was more proteolytic than Candida metapsilosis . Candida glabrata and Candida dubliniensis showed very low ability to form biofilm on polystyrene microtiter plates. We have demonstrated here diverse peculiarities of different Candida species regarding the ability to express virulence factors. This study will contribute for the understanding of the natural history and pathogenesis of yeasts belonging to the genus Candida in the oral cavity of patients who were submitted to kidney transplant and are under immunosuppressive therapies.