Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair

[Display omitted] Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine–thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate e...

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 27; no. 2; pp. 278 - 284
Main Authors Hashiya, Fumitaka, Ito, Shinji, Sugiyama, Hiroshi
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.01.2019
Subjects
Bromouracil
Electron transfer
Mitochondria
Photochemical
TFAM
Electron transfer
TFAM
Mitochondria
Photochemical
Bromouracil
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ISSN0968-0896
1464-3391
1464-3391
DOI10.1016/j.bmc.2018.11.044

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Summary:[Display omitted] Electron transfer through π-stacked arrays of double-stranded DNA contributes to the redox chemistry of bases, including guanine oxidation and thymine–thymine dimer repair by photolyase. 5-Bromouracil is an attractive photoreactive thymine analogue that can be used to investigate electron transfer in DNA, and is a useful probe for protein–DNA interaction analysis. In the present study using BrU we found that UV irradiation facilitated electron injection from mitochondrial transcription factor A into DNA. We also observed that this electron injection could lead to repair of a thymine–thymine dimer.
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ISSN:0968-0896
1464-3391
1464-3391
DOI:10.1016/j.bmc.2018.11.044