Targeting NLRP3 Inflammasome in the Treatment Of Diabetes and Diabetic Complications: Role of Natural Compounds from Herbal Medicine

Diabetes, a common metabolic disease with various complications, is becoming a serious global health pandemic. So far there are many approaches in the management of diabetes; however, it still remains irreversible due to its complicated pathogenesis. Recent studies have revealed that nucleotide-bind...

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Published inAging and disease Vol. 12; no. 7; pp. 1587 - 1604
Main Authors Bai, Ying, Mu, Qianqian, Bao, Xueli, Zuo, Jiacheng, Fang, Xin, Hua, Jing, Zhang, Dongwei, Jiang, Guangjian, Li, Ping, Gao, Sihua, Zhao, Dandan
Format Journal Article
LanguageEnglish
Published JKL International 01.10.2021
JKL International LLC
Subjects
Care and treatment
Complications and side effects
Diabetes
Genetic aspects
Health aspects
Natural products
Review
China
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Summary:Diabetes, a common metabolic disease with various complications, is becoming a serious global health pandemic. So far there are many approaches in the management of diabetes; however, it still remains irreversible due to its complicated pathogenesis. Recent studies have revealed that nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a vital role in the progression of diabetes and many of its complications, making it a promising therapeutic target in pharmaceutical design. Natural derived herbal medicine, known for its utilization of natural products such as herbs or its bioactive ingredients, is shown to be able to ameliorate hyperglycemia-associated symptoms and to postpone the progression of diabetic complications due to its anti-inflammatory and anti-oxidative properties. In this review, we summarized the role of NLRP3 inflammasome in diabetes and several diabetic complications, as well as 31 active compounds that exert therapeutic effect on diabetic complications via inhibiting NLRP3 inflammasome. Improving our understanding of these promising candidates from natural compounds in herbal medicine targeting NLRP3 inflammasome inspires us the relationship between inflammation and metabolic disorders, and also sheds light on searching potential agents or therapies in the treatment of diabetes and diabetic complications. Key words: NLRP3 inflammasome; diabetes; diabetic complications; natural compounds; herbal medicine
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these authors equally contributed this work.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2021.0318