Lysophosphatidic acid (LPA) and its receptors

Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have...

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Published inCurrent opinion in pharmacology Vol. 9; no. 1; pp. 15 - 23
Main Authors Noguchi, Kyoko, Herr, Deron, Mutoh, Tetsuji, Chun, Jerold
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2009
Subjects
Animals
Humans
Internal Medicine
Lysophospholipids - physiology
Medical Education
Nervous System - metabolism
Pain - metabolism
Peripheral Nervous System Diseases - metabolism
Receptors, Lysophosphatidic Acid - agonists
Receptors, Lysophosphatidic Acid - antagonists & inhibitors
Receptors, Lysophosphatidic Acid - physiology
Signal Transduction
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Summary:Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In addition, small molecule agonists and antagonists have been reported. Here we review recent data on the nervous system functions of LPA signaling, and summarize data on reported agonists and antagonists of LPA receptors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2008.11.010