Glycolipid-mediated basophil activation in alpha-gal allergy

Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 146; no. 2; pp. 450 - 452
Main Authors Iweala, Onyinye I., Choudhary, Shailesh K., Addison, Claire T., Batty, Cole J., Kapita, Camille M., Amelio, Claire, Schuyler, Alexander J., Deng, Shenglou, Bachelder, Eric M., Ainslie, Kristy M., Savage, Paul B., Brennan, Patrick J., Commins, Scott P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2020
Subjects
Allergens - immunology
alpha-Galactosidase - immunology
Antigens, CD1d - metabolism
Basophil Degranulation Test
Basophils - immunology
Cell Degranulation
Cells, Cultured
Food Hypersensitivity - immunology
Glycolipids - immunology
Humans
Immunoglobulin E - metabolism
Red Meat
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Summary:Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2020.02.006