Optogenetic Approaches for Controlling Seizure Activity

Highlights • Optogenetics shows great promise as a direct neuromodulatory therapy for halting seizure activity. • The ability to activate or inhibit specific cell types has resulted in various approaches for halting seizure activity in rodent models of epilepsy. • These approaches offer a promising...

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Bibliographic Details
Published inBrain stimulation Vol. 9; no. 6; pp. 801 - 810
Main Authors Tung, Jack K, Berglund, Ken, Gross, Robert E
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Subjects
Animals
Epilepsy
Humans
Neurology
Neuromodulation
Optogenetics
Optogenetics - methods
Seizures - therapy
epilepsy
neuromodulation
Optogenetics
Neuromodulation
Epilepsy
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Summary:Highlights • Optogenetics shows great promise as a direct neuromodulatory therapy for halting seizure activity. • The ability to activate or inhibit specific cell types has resulted in various approaches for halting seizure activity in rodent models of epilepsy. • These approaches offer a promising means of controlling seizure activity, but several challenges still need to be addressed before they can be effectively translated into viable therapies for patients with epilepsy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2016.06.055