Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation

• Published in: Caries research Vol. 56; no. 3; pp. 187 - 196
• Main Authors: Bulthuis, Marjolein S., van Gennip, Lucky L.A., Thomas, Renske Z., Bronkhorst, Ewald M., Laheij, Alexa M.G.A., Raber-Durlacher, Judith E., Rozema, Frederik R., Brennan, Michael T., von Bültzingslöwen, Inger, Blijlevens, Nicole M.A., van Leeuwen, Stephanie J.M., Huysmans, Marie-Charlotte D.N.J.M.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.11.2022
• Subjects: Analysis; blood; care; Care and treatment; Dental caries; Dentistry; Development and progression; Haematopoietic stem cell transplantation; Hematopoietic stem cells; Hyposalivation; Medical centers; Medical research; Medicine, Experimental; Odontologi; Oral Surgery & Medicine; Research Article; salivary flow; Stem cells; Transplantation; Netherlands; Hyposalivation; Haematopoietic stem cell transplantation; Dental caries
• ISSN: 0008-6568; 1421-976X
• DOI: 10.1159/000525599

Haematopoietic stem cell transplantation (HSCT) preceded by a conditioning regimen is an established treatment option for many haematological diseases. Decreased salivary flow rates after HSCT may increase caries risk. We aim to estimate the extent to which caries lesions develop or progress in adult HSCT recipients and assess its association with salivary flow rates. A multi-centre prospective observational study was conducted in which patients receiving HSCT were followed up for 18 months. We included 116 patients (median age 56 years, 43% female) from two medical centres in the Netherlands. Unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) were collected, and full caries charts were made before HSCT and 3, 6, 12, and 18 months post-HSCT. Caries was scored according to the ICDAS criteria by trained dentist-examiners. New dentine lesions or lesion progression into dentine (ICDAS ≥4 or cavitated root lesions) occurred in 32% of patients over 18 months. The median number of affected surfaces was 2 (range: 1–12) per patient with caries progression. The influence of hyposalivation of unstimulated saliva (<0.2 mL/min) and stimulated saliva (<0.7 mL/min) at baseline and after 3 months on caries progression was determined with a negative binomial regression model. Hyposalivation of SWS 3 months after HSCT was a significant risk indicator for caries progression (incidence rate ratio: 5.30, 95% CI: 2.09–13.4, p < 0.001), while hyposalivation of SWS at baseline and hyposalivation of UWS were not. We conclude that caries progression is a common oral complication in patients after HSCT, and stimulated hyposalivation shortly after treatment is a significant risk indicator for caries progression.