Policing the cytosol—bacterial-sensing inflammasome receptors and pathways

Highlights ► Recent developments implicate simultaneous engagement of multiple NLR inflammasomes. ► Recent data indicate the possibility of alternate outputs of NLR inflammasomes. ► Novel regulators of NLR inflammasomes integrate multiple immune signaling pathways. ► Elucidation of caspase-11 functi...

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 25; no. 1; pp. 34 - 39
Main Authors Ng, Tessie M, Kortmann, Jens, Monack, Denise M
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2013
Subjects
Allergy and Immunology
Animals
Caspases - immunology
Cytosol - immunology
Humans
Immunity, Innate
Inflammasomes - immunology
Mice
Multiprotein Complexes - immunology
Nod Signaling Adaptor Proteins - immunology
Signal Transduction
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Summary:Highlights ► Recent developments implicate simultaneous engagement of multiple NLR inflammasomes. ► Recent data indicate the possibility of alternate outputs of NLR inflammasomes. ► Novel regulators of NLR inflammasomes integrate multiple immune signaling pathways. ► Elucidation of caspase-11 function in cytosolic-sensing pathways.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.11.009