Natural Killer T cell obsession with self-antigens

• Published in: Current opinion in immunology Vol. 25; no. 2; pp. 168 - 173
• Main Authors: Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2013
• Subjects: Allergy and Immunology; Autoantigens - immunology; Humans; Natural Killer T-Cells - immunology

Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate ty...