Natural Killer T cell obsession with self-antigens

Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate ty...

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 25; no. 2; pp. 168 - 173
Main Authors Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Allergy and Immunology
Autoantigens - immunology
Humans
Natural Killer T-Cells - immunology
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Summary:Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate type-I NKT cells. ► The main mouse model for the study of type-I NKT cell autoreactivity is imperfect.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2013.01.002