Natural Killer T cell obsession with self-antigens

Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate ty...

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Published inCurrent opinion in immunology Vol. 25; no. 2; pp. 168 - 173
Main Authors Gapin, Laurent, Godfrey, Dale I, Rossjohn, Jamie
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Allergy and Immunology
Autoantigens - immunology
Humans
Natural Killer T-Cells - immunology
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Abstract Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate type-I NKT cells. ► The main mouse model for the study of type-I NKT cell autoreactivity is imperfect.
AbstractList Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo . ► Several different self-antigens can stimulate type-I NKT cells. ► The main mouse model for the study of type-I NKT cell autoreactivity is imperfect.
► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I NKT TCRs. ► There are multiple ways to trigger a type-I NKT response in vivo. ► Several different self-antigens can stimulate type-I NKT cells. ► The main mouse model for the study of type-I NKT cell autoreactivity is imperfect. Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, increasing evidence suggest that recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT T cell receptor engages self-antigens and the nature of these self-antigens.
Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, increasing evidence suggest that recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT T cell receptor engages self-antigens and the nature of these self-antigens.
Natural Killer T cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical MHC molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, the recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT TCR engages self-antigens and the nature of these self-antigens.
Author Godfrey, Dale I
Gapin, Laurent
Rossjohn, Jamie
AuthorAffiliation 2 Department of Microbiology & Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
1 Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
3 Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
AuthorAffiliation_xml – name: 3 Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
– name: 1 Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23384972$$D View this record in MEDLINE/PubMed
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Snippet Highlights ► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon...
► NKT cells are inherently reactive to self-antigens presented by CD1d molecules. ► Self-antigens are made to mimic foreign antigens upon recognition by type-I...
Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex...
Natural Killer T cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical MHC molecule CD1d. Two categories of NKT...
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SubjectTerms Allergy and Immunology
Autoantigens - immunology
Humans
Natural Killer T-Cells - immunology
Title Natural Killer T cell obsession with self-antigens
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0952791513000034
https://dx.doi.org/10.1016/j.coi.2013.01.002
https://www.ncbi.nlm.nih.gov/pubmed/23384972
https://search.proquest.com/docview/1349093701
https://pubmed.ncbi.nlm.nih.gov/PMC3646945
Volume 25
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