Effect of Hydrolysable Tannins and Anthocyanins on Recurrent Urinary Tract Infections in Nephropathic Patients: Preliminary Data

• Published in: Nutrients Vol. 13; no. 2; p. 591
• Main Authors: Noce, Annalisa, Di Daniele, Francesca, Campo, Margherita, Di Lauro, Manuela, Pietroboni Zaitseva, Anna, Di Daniele, Nicola, Marrone, Giulia, Romani, Annalisa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.02.2021; MDPI
• Subjects: Acids; adjuvants; Aesculus - chemistry; Aged; Anthocyanin; anthocyanins; Anthocyanins - administration & dosage; Anti-Infective Agents - administration & dosage; antibiotic resistance; Antibiotics; Antimicrobial agents; antimicrobial properties; Antioxidants; bacteria; bioactive compounds; Blood; Body Composition; Calibration; Care and treatment; Castanea; Chromatography; Diabetes; Dietary Supplements; Diseases; drug therapy; E coli; erythrocyte sedimentation rate; Female; Food; Health aspects; Humans; Hydrolyzable Tannins - administration & dosage; laboratories; Male; males; Medical examination; Microorganisms; Middle Aged; Molecular weight; Phenols; Physiological aspects; Phytotherapy; Pilot Projects; Polyphenols; Preliminary Data; proanthocyanidins; Quality of Life; quercetin; Recurrence; Relapse; Renal Insufficiency, Chronic - complications; Sex Factors; urinalysis; urinary tract; Urinary tract diseases; Urinary tract infections; Urinary Tract Infections - microbiology; Urinary Tract Infections - prevention & control; Urogenital system; Vaccinium macrocarpon - chemistry; United States > US; Italy; hydrolysable tannins; chronic kidney disease; anthocyanins; urinary tract infections; cranberry; quality of life; Sweet Chestnut
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13020591

Urinary tract infections (UTIs) are caused by uropathogenic microorganism colonization. UTIs often require an antibiotic therapy that can cause the selection of antibiotic-resistant bacterial strains. A natural bioactive compound may represent a valid therapeutic adjuvant approach, in combination with drug therapy. In this paper, we present a pilot study, based on the administration of an oral food supplement (OFS), containing chestnut tannins and anthocyanins, to nephropathic patients suffering from recurrent UTIs (16 treated patients with 1 cp/day and 10 untreated patients). We performed laboratory tests and quality of life and body composition assessments, at T0 (baseline) and T1 (after 6 weeks OFS assumption). The analysis of OFS was performed by HPLC-DAD-MS for its content in polyphenols and by in vitro tests for its antioxidative and anti-free radical activities. In each capsule, polyphenol content was 6.21 mg (4.57 mg hydrolysable tannins, 0.94 mg anthocyanosides, 0.51 mg proanthocyanidins, 0.18 mg quercetin derivatives). A significant reduction of erythrocyte sedimentation rate was observed only in male patients. Urinalysis showed a significant reduction of leukocytes in both genders, whereas urinary bacterial flora at T1 significantly decreased only in male subjects. Tannins seem to exert an antimicrobial action according to gender, useful to counteract the recurrence of UTIs.