Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause

This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date,...

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Bibliographic Details
Published inObstetrics and gynecology clinics of North America Vol. 45; no. 4; p. 751
Main Authors Morgan, Kelly N, Derby, Carol A, Gleason, Carey E
Format Journal Article
LanguageEnglish
Published United States 01.12.2018
Subjects
Aging - physiology
Cognition - physiology
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognition Disorders - prevention & control
Estrogen Replacement Therapy
Estrogens - therapeutic use
Evidence-Based Medicine
Female
Humans
Menopause - metabolism
Menopause - physiology
Neuroprotection
Perimenopause
Reproductive Health
Women's Health
Women’s Health Initiative
Hormone therapy
Estrogens
Menopause
Cognition
Study of women across the nation
Early versus late intervention trial with estradiol
Kronos early estrogen prevention study
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Summary:This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory results from major hormone therapy trials to date, evidence for the "timing hypothesis," and closes with recommendations for future research and for practicing clinicians.
ISSN:1558-0474
DOI:10.1016/j.ogc.2018.07.011