A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys

• Published in: Journal of Virology Vol. 78; no. 18; pp. 9998 - 10008
• Main Authors: GUIRAKHOO, F, ZHANG, Z, LANG, J, FOURNIER, C, BARRERE, B, DELAGRAVE, S, MONATH, T. P, MYERS, G, JOHNSON, B. W, PUGACHEV, K, NICHOLS, R, BROWN, N, LEVENBOOK, I, DRAPER, K, CYREK, S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2004
• Subjects: Aedes; Amino Acid Substitution; Animals; Animals, Suckling; Antibodies, Viral - blood; Arboviroses; Biological and medical sciences; Cell Line; Cercopithecus aethiops; Chimera - genetics; Dengue - etiology; Dengue - pathology; Dengue - prevention & control; Dengue Virus - genetics; Dengue Virus - pathogenicity; Female; Fundamental and applied biological sciences. Psychology; Human viral diseases; Humans; Infectious diseases; Macaca fascicularis; Macaca mulatta; Male; Medical sciences; Membrane Fusion; Mice; Mice, Inbred ICR; Microbiology; Miscellaneous; Models, Molecular; Pathogenesis and Immunity; Point Mutation; Tropical viral diseases; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - genetics; Vero Cells; Viral diseases; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Viral Vaccines - genetics; Viremia - etiology; Virology; Virulence - genetics; Yellow fever; Yellow Fever - etiology; Yellow Fever Vaccine - genetics; Yellow fever virus - genetics; Yellow fever virus - pathogenicity; Microbiology; Viremia; Dengue 1; Monkey; Dengue virus; Flavivirus; Prevention; Arbovirus disease; Primates; Yellow fever group virus; Yellow fever; Dengue; Rodentia; Vaccine; Dengue virus 1; Protein; Virology; Infection; Virus; Immunoprophylaxis; Vertebrata; Mammalia; Mouse; Viral disease; Dengue group virus; Aminoacid; Animal; Flaviviridae; Yellow fever virus
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.78.18.9998-10008.2004

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