Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality

• Published in: Medical hypotheses Vol. 146; p. 110396
• Main Authors: Macias-Verde, David, Lara, Pedro C., Burgos-Burgos, Javier
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.01.2021
• Subjects: Aerosols; Air Microbiology; Air Pollution, Radioactive - adverse effects; Alzheimer’s disease; ARDS; Causality; Climate Change; COVID-19; COVID-19 - etiology; COVID-19 - mortality; Humans; Inflammasomes - metabolism; Inflammasomes - radiation effects; Inflammation - etiology; Models, Biological; Nervous System Diseases - etiology; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; Pandemics; Particle Size; Particulate Matter - adverse effects; Pneumonia - etiology; Pollution; Radioactivity; SARS-CoV-2 - pathogenicity; oAβ; THP-1; Na+,K+-ATPase; ORF; Sv; SARS-COV-2; CO2; K; NLRP3 inflammasome; USEPA; COVID-19; NO2; NF-κB; Pollution; IFN-γ; TSNA; PM2.5; SO2; NLRP3; TGF-β; TLR; mBq; ARDS; AT1; Radioactivity; WHO; GSDMD; AD; Alzheimer’s disease; HSPCs; CO; mSv; PAMP; TNF-α; Ca2; DNA; ROS; PM10; µSv; ACE-2; MERS; DAMP
• ISSN: 0306-9877; 1532-2777; 1532-2777
• DOI: 10.1016/j.mehy.2020.110396

We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.