Dental Diseases Increase Risk of Aortic Arch Calcification Independent of Renal Dysfunction in Older Adults: Shenzhen Community Cohort Study

Many studies have documented that dental diseases were associated with an increased risk of cardiovascular diseases. Aortic arch calcification (AoAC) is a powerful predictor of cardiovascular diseases. However, whether the status of dental health is associated with AoAC is still unknown. 9463 partic...

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Published inMetabolites Vol. 12; no. 12; p. 1258
Main Authors Yin, Li, Zhang, Zhengzhipeng, Xie, Changming, Luo, Dongling, He, Wanbing, Huang, Suli, Huang, Hui
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2022
MDPI
Subjects
Aged
Aorta, Thoracic
Aortic arch
aortic arch calcification
Blood pressure
Calcification
Calcification (ectopic)
Cardiovascular diseases
Cohort analysis
Complications and side effects
Cross-sectional studies
Dental caries
dental diseases
Dental disorders
Diabetes
Fluoridation
Health aspects
Hyperlipidemia
Hypertension
Kidney diseases
Medical research
Medicine, Experimental
Physiological aspects
Radiography
renal dysfunction
Renal function
Risk factors
Teeth
Tooth diseases
X-rays
China
dental diseases
renal dysfunction
aortic arch calcification
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Summary:Many studies have documented that dental diseases were associated with an increased risk of cardiovascular diseases. Aortic arch calcification (AoAC) is a powerful predictor of cardiovascular diseases. However, whether the status of dental health is associated with AoAC is still unknown. 9463 participants over the age of 60 from Shenzhen community centers were included in the cross-sectional analysis. Physical examination data, blood biochemical tests, and AoAC scores calculated by chest radiography were collected and analyzed. Among them, 2630 participants were followed up for AoAC progression up to 36 months. Participants with AoAC suffered more tooth loss than those without AoAC (77.62% vs. 72.91%; p < 0.001). Association rule analysis suggested a strong association between dental diseases and AoAC. Tooth loss or decay increased the risk of AoAC progression (HR 1.459; 95%CI 1.284−1.658) after adjusting other risk factors including renal dysfunction. Dental diseases are potential predictors for AoAC in elderly people, which are independent of renal dysfunction.
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These authors contributed equally to this work.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo12121258