Superparamagnetic nanoarchitectures for disease-specific biomarker detection
The detection of clinically relevant disease-specific biomolecules, including nucleic acids, circulating tumor cells, proteins, antibodies, and extracellular vesicles, has been indispensable to understand their functions in disease diagnosis and prognosis. Therefore, a biosensor for the robust, ultr...
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| Published in | Chemical Society reviews Vol. 48; no. 24; pp. 5717 - 5751 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
09.12.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The detection of clinically relevant disease-specific biomolecules, including nucleic acids, circulating tumor cells, proteins, antibodies, and extracellular vesicles, has been indispensable to understand their functions in disease diagnosis and prognosis. Therefore, a biosensor for the robust, ultrasensitive, and selective detection of these low-abundant biomolecules in body fluids (blood, urine, and saliva) is emerging in current clinical research. In recent years, nanomaterials, especially superparamagnetic nanomaterials, have played essential roles in biosensing due to their intrinsic magnetic, electrochemical, and optical properties. However, engineered multicomponent magnetic nanoparticle-based current biosensors that offer the advantages of excellent stability in a complex biomatrix; easy and alterable biorecognition of ligands, antibodies, and receptor molecules; and unified point-of-care integration have yet to be achieved. This review introduces the recent advances in superparamagnetic nanostructures for electrochemical and optical biosensing for disease-specific biomarkers. This review emphasizes the synthesis, biofunctionalization, and intrinsic properties of nanomaterials essential for robust, ultrasensitive biosensing. With a particular emphasis on nanostructure-based electrochemical and optical detection of disease-specific biomarkers such as nucleic acids (DNA and RNA), proteins, autoantibodies, and cells, this review also chronicles the needs and challenges of nanoarchitecture-based detection. These summaries provide further insights for researchers to inspire their future work on the development of nanostructures for integrating into biosensing and devices for a broad field of applications in analytical sensing and in clinic.
Synthesis, bio-functionalization, and multifunctional activities of superparamagnetic-nanostructures have been extensively reviewed with a particular emphasis on their uses in a range of disease-specific biomarker detection and associated challenges. |
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| Bibliography: | Dr Shiddiky is a Senior Lecturer in the School of Environment and Science at Griffith University (Nathan Campus). He obtained his PhD from Pusan National University, South Korea, in 2007. Following his PhD work, he was a postdoctoral fellow at Monash University, ARC DECRA fellow at the University of Queensland, and NHMRC CD fellow at Griffith University. His research focuses on the development of new liquid biopsy methods and point-of-care devices for early detection of cancer and other diseases. Currently, he is involved in developing functional nanomaterial-based portable devices for the detection and management of various plant and food-related diseases. Dr Hossain is currently a Senior Lecturer in the School of Mechanical and Mining Engineering at UQ. He obtained his PhD degree in Materials Science and Engineering, The University of Wollongong (UoW), Australia, in 2008. He was then employed as a Postdoctoral Research Fellow at the University of Geneva, Switzerland. He was awarded the prestigious DECRA Fellowship from the Australian Research Council (ARC) in 2013. His research experience in various institutes and in industry around the world has been mainly focused on the fabrication and characterization of superconducting materials and magnetically triggered nanoparticles for medical and energy applications. Mostafa Kamal Masud is a PhD student at the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ), Australia. His research focuses on the design and translation of bio-favourable engineered nanostructured superparamagnetic materials towards the development of molecular diagnostics (optical and electrochemical nanobiosensors, magnetophoretic-based and paper-based microfluidic devices) for cancer. Prior to starting PhD, he obtained his Master of Science and Bachelor of Science degrees in Chemistry from Shahjalal University of Science and Technology (SUST), Sylhet-3114, Bangladesh. Dr Jongbeom Na received his PhD degree (2017) from the Department of Chemical and Biomolecular Engineering at Yonsei University (Republic of Korea). Until 2018, he worked as a Research Engineer at Chemical Laboratory of SK Chemicals Co., Ltd. Currently, he is working as a research fellow at AIBN, the University of Queensland and MANA, NIMS. His major research interest is in the design and synthesis of functional nanomaterials, organic-inorganic hybrid materials, and their applications. Professor Yamauchi received his Bachelor's degree (2003), Master's degree (2004), and PhD (2007) from the Waseda University, Japan. Currently, he is a senior group leader at AIBN and a Professor at the School of Chemical Engineering, UQ. He concurrently serves as an honorary group leader of NIMS, a visiting/honorary professor at several universities in the world, and an associate editor of Journal of Materials Chemistry A, RSC. He has published more than 700 papers in international refereed journals with >35 000 citations (h-index > 95). He has been selected as one of the Highly Cited Researchers in Chemistry in the last 4 years. |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c9cs00174c |