SiiE Is Secreted by the Salmonella enterica Serovar Typhimurium Pathogenicity Island 4-Encoded Secretion System and Contributes to Intestinal Colonization in Cattle

• Published in: Infection and Immunity Vol. 75; no. 3; pp. 1524 - 1533
• Main Authors: Morgan, Eirwen, Bowen, Alison J, Carnell, Sonya C, Wallis, Timothy S, Stevens, Mark P
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2007
• Subjects: Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cattle; Genomic Islands - physiology; Intestinal Mucosa - microbiology; Membrane Proteins - genetics; Membrane Proteins - metabolism; Molecular Pathogenesis; Salmonella enterica; Salmonella typhimurium - genetics; Salmonella typhimurium - pathogenicity; Virulence Factors - genetics; Virulence Factors - physiology
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.01438-06

Here we report that Salmonella enterica serovar Typhimurium pathogenicity island 4 carries a type I secretion system (siiCDF) which secretes an ~600-kDa protein (encoded by siiE). SiiE is surface expressed, and its production is regulated by HilA. SiiE and SiiF influence colonization in cattle and the invasion of bovine enterocytes.