Maternal serum cytokine levels and risk of bipolar disorder

Highlights • Cases with bipolar disorder (BD) and matched controls were identified. • Nine cytokines were measured in archived prenatal maternal serum samples. • Among cases overall, the cytokine levels were not associated with risk of BD. • Lower levels of IL-4 and IL-6 were observed in BD cases wi...

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Published inBrain, behavior, and immunity Vol. 63; pp. 108 - 114
Main Authors Cheslack-Postava, Keely, Cremers, Serge, Bao, Yuanyuan, Shen, Ling, Schaefer, Catherine A, Brown, Alan S
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.07.2017
Subjects
Allergy and Immunology
Bipolar disorder
Bipolar Disorder - immunology
Case-Control Studies
Cohort Studies
Cytokines
Cytokines - blood
Female
Humans
IL-4
IL-6
Immune
Influenza, Human - complications
Interleukin-4 - blood
Interleukin-6 - blood
Maternal
Pregnancy
Pregnancy Complications, Infectious - immunology
Prenatal
Prenatal Exposure Delayed Effects
Psychiatry
Risk Factors
Prenatal
Maternal
Cytokines
Immune
IL-4
Bipolar disorder
IL-6
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Summary:Highlights • Cases with bipolar disorder (BD) and matched controls were identified. • Nine cytokines were measured in archived prenatal maternal serum samples. • Among cases overall, the cytokine levels were not associated with risk of BD. • Lower levels of IL-4 and IL-6 were observed in BD cases without psychotic features. • Findings varied by trimester.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.07.160