Autoinflammatory pustular neutrophilic diseases

This article provides a new categorization of inflammatory pustular dermatoses in the context of recent genetic and biological insights. Monogenic diseases with pustular phenotypes are discussed, including deficiency of interleukin 1 receptor antagonist, deficiency of the interleukin 36 receptor ant...

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Bibliographic Details
Published inDermatologic clinics Vol. 31; no. 3; p. 405
Main Authors Naik, Haley B, Cowen, Edward W
Format Journal Article
LanguageEnglish
Published United States 01.07.2013
Subjects
Autoimmune Diseases - diagnosis
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Diagnosis, Differential
Humans
Neutrophils - immunology
Skin Diseases, Vesiculobullous - diagnosis
Skin Diseases, Vesiculobullous - drug therapy
Skin Diseases, Vesiculobullous - immunology
Deficiency of IL-1 receptor antagonist (DIRA)
Subcorneal pustular dermatosis
PAPA syndrome
Pustular psoriasis
Palmoplantar pustulosis
SAPHO syndrome
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Summary:This article provides a new categorization of inflammatory pustular dermatoses in the context of recent genetic and biological insights. Monogenic diseases with pustular phenotypes are discussed, including deficiency of interleukin 1 receptor antagonist, deficiency of the interleukin 36 receptor antagonist, CARD14-associated pustular psoriasis, and pyogenic arthritis, pyoderma gangrenosum, and acne. How these new genetic advancements may inform how previously described pustular diseases are viewed, including pustular psoriasis and its clinical variants, with a focus on historical classification by clinical phenotype, is also discussed.
ISSN:1558-0520
DOI:10.1016/j.det.2013.04.001