Heterotopic Ossification Following Upper Extremity Injury

Heterotopic ossification (HO) presents a substantial barrier to rehabilitation for patients with severe burns or trauma. Although surgical excision is a mainstay of management for this condition, this is unable to address the chronic sequelae of HO, including chronic pain, joint contractures, nerve...

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Bibliographic Details
Published inHand clinics Vol. 33; no. 2; p. 363
Main Authors Agarwal, Shailesh, Loder, Shawn, Levi, Benjamin
Format Journal Article
LanguageEnglish
Published United States 01.05.2017
Subjects
Arm Injuries - complications
Burns - complications
Contracture - complications
Elbow Joint
Humans
Joint Dislocations - complications
Ossification, Heterotopic - etiology
Range of Motion, Articular
Heterotopic ossification
Upper extremity
Burn injury
Elbow
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Summary:Heterotopic ossification (HO) presents a substantial barrier to rehabilitation for patients with severe burns or trauma. Although surgical excision is a mainstay of management for this condition, this is unable to address the chronic sequelae of HO, including chronic pain, joint contractures, nerve dysfunction, and open wounds. Current therapeutic modalities are aimed at excision and the prevention of recurrence using nonsteroidal antiinflammatory drugs (NSAIDs) or radiation therapy. Research is now focused on identifying alternative strategies to prevent the initial occurrence of HO through NSAIDs and novel inhibitors of the bone morphogenetic protein signaling pathway.
ISSN:1558-1969
DOI:10.1016/j.hcl.2016.12.013