Plasma cells: finding new light at the end of B cell development

Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulati...

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Bibliographic Details
Published inNature immunology Vol. 2; no. 12; pp. 1103 - 1108
Main Author Calame, Kathryn L
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.12.2001
Subjects
Animals
Antigens, Differentiation, B-Lymphocyte - metabolism
B-Lymphocytes - immunology
Cell Differentiation
Cell Lineage
Immunoglobulins - biosynthesis
Immunologic Memory
Mice
Models, Immunological
Plasma Cells - immunology
Receptors, Chemokine - metabolism
Spleen - immunology
Transcription Factors - physiology
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Summary:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements for early B cell development, little information has been available on plasma cells. However, more recent work-including studies on genetically altered mice and data from microarray analyses-has begun to identify the regulatory cascades that initiate and maintain the plasma cell phenotype. This review will summarize our current understanding of the molecules that regulate commitment to a plasma cell fate and those that mediate plasma cell function.
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ISSN:1529-2908
1529-2916
DOI:10.1038/ni1201-1103