Assessment of four different cardiac softwares for evaluation of LVEF with CZT-SPECT vs CMR in 48 patients with recent STEMI

• Published in: Journal of nuclear cardiology Vol. 27; no. 6; pp. 2017 - 2026
• Main Authors: Plateau, Antoine, Bouvet, Clément, Merlin, Charles, Pereira, Bruno, Barres, Bertrand, Clerfond, Guillaume, Cachin, Florent, Cassagnes, Lucie
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Inc 01.12.2020; Springer International Publishing; Springer Nature B.V; Springer Verlag
• Subjects: Adult; Aged; Cadmium; Cameras; Cancer; Cardiology; Diastole; Ejection fraction; Electrocardiography; end-diastolic volume; end-systolic volume; Female; Gated Blood-Pool Imaging - methods; Heart attacks; Humans; Image Processing, Computer-Assisted - instrumentation; Image Processing, Computer-Assisted - methods; Imaging; Left ventricular ejection fraction; Life Sciences; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; MPI CZT-SPECT; NMR; Nuclear magnetic resonance; Nuclear Medicine; Original Article; Radiology; Software; Software packages; softwares; ST Elevation Myocardial Infarction - diagnostic imaging; Stroke Volume; Studies; Technetium Tc 99m Sestamibi; Tellurium; Tomography, Emission-Computed, Single-Photon - methods; Ventricular Dysfunction, Left; Ventricular Function, Left; Zinc; softwares; LVEF; end-systolic volume; CMR; ESV; MX; 4MD; ECTb; Left ventricular ejection fraction; EDV; end-diastolic volume; QGS; MPI CZT-SPECT
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1007/s12350-018-01493-y

To compare, vs CMR, four softwares: quantitative gated SPECT (QGS), myometrix (MX), corridor 4DM (4DM), and Emory toolbox (ECTb) to evaluate left ventricular ejection fraction (LVEF), end-systolic (ESV), and end-diastolic volumes (EDVs) by gated MPI CZT-SPECT. 48 patients underwent MPI CZT-SPECT and CMR 6 weeks after STEMI, LV parameters were measured with four softwares at MPI CZT-SPECT vs CMR. We evaluated (i) concordance and correlation between MPI CZT-SPECT and CMR, (ii) concordance MPI CZT-SPECT/CMR for the categorical evaluation of the left ventricular dysfunction, and (iii) impacts of perfusion defects > 3 segments on concordance. LVEF: LCC QGS/CMR = 0.81 [+ 2.2% (± 18%)], LCC MX/CMR = 0.83 [+ 1% (± 17.5%)], LCC 4DM/CMR = 0.73 [+ 3.9% (± 21%)], LCC ECTb/CMR = 0.69 [+ 6.6% (± 21.1%)]. ESV: LCC QGS/CMR = 0.90 [− 8 mL (± 40 mL)], LCC MX/CMR = 0.90 [− 9 mL (± 36 mL)], LCC 4DM/CMR = 0.89 [+ 4 mL (± 45 mL)], LCC ECTb/CMR = 0.87 [− 3 mL (± 45 mL)]. EDV: LCC QGS/CMR = 0.70 [− 16 mL (± 67 mL)], LCC MX/CMR = 0.68 [− 21 mL (± 63 mL], LCC 4DM/CMR = 0.72 [+ 9 mL (± 73 mL)], LCC ECTb/CMR = 0.69 [+ 10 mL (± 70 mL)]. QGS and MX were the two best-performing softwares to evaluate LVEF after recent STEMI.