Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study

• Published in: European heart journal Vol. 29; no. 5; pp. 673 - 679
• Main Authors: Chocron, Sidney, Baillot, Richard, Rouleau, Jean Lucien, Warnica, Wayne J., Block, Pierre, Johnstone, David, Myers, Martin G., Calciu, Cristina Dana, Nozza, Anna, Martineau, Pierre, van Gilst, Wiek H.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2008; Oxford Publishing Limited (England)
• Subjects: Angioplasty; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - methods; Blood Vessel Prosthesis - adverse effects; Coronary artery bypass; Coronary Artery Bypass - methods; Coronary Disease - therapy; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Myocardial Reperfusion Injury - etiology; Percutaneous coronary; Prosthesis Failure; Reoperation - methods; Stents - adverse effects; Stroke Volume - physiology; Transluminal; Treatment Outcome; Transluminal; Coronary artery bypass; Percutaneous coronary; Angioplasty
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehn026

Aim To determine the impact of previous coronary artery revascularization by percutaneous transluminal coronary angioplasty and/or stenting (PCI) on outcome after subsequent coronary artery bypass grafting (CABG). Methods and results The ischaemia management with Accupril post-bypass Graft via Inhibition of the coNverting Enzyme (IMAGINE) trial, conducted between November 1999 and September 2004, tested whether early initiation of an angiotensin-converting enzyme inhibitor post-CABG, in stable patients with LVEF ≥40%, would reduce cardiovascular events. Of the 2489 patients included in the IMAGINE trial, undergoing their first operation, 430 had a history of PCI prior to surgery (PCI group), and 2059 were referred to surgery without previous PCI (non-PCI group). There was a significant increase in the primary IMAGINE endpoint in the PCI group, HR = 1.53 [1.17–1.98], P = 0.0016. Coronary revascularization, HR = 1.80 [1.13–2.87], P = 0.014, unstable angina requiring hospitalization, HR = 2.43 [1.52–3.89], P = 0.0002, were the two individual components that significantly increased in the PCI group, even when adjusted for baseline characteristics (age, sex, history of myocardial infarction or stroke, diabetes, treatment group, or off-pump surgery). Conclusion Patients with left ventricular ejection fraction ≥40% having a history of PCI prior to surgery had a worse outcome post-CABG than those with no prior PCI. Further studies are needed to investigate whether these results apply for drug eluting stents.