Establishing the Role of PPARβ/δ in Carcinogenesis

• Published in: Trends in endocrinology and metabolism Vol. 26; no. 11; pp. 595 - 607
• Main Authors: Peters, Jeffrey M, Gonzalez, Frank J, Müller, Rolf
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.11.2015
• Subjects: Animals; cancer; Carcinogenesis - drug effects; Carcinogenesis - metabolism; chemoprevention; Endocrinology & Metabolism; Humans; mechanisms; peroxisome proliferator-activated receptor-β/δ; PPAR delta - agonists; PPAR delta - antagonists & inhibitors; PPAR delta - metabolism; PPAR-beta - agonists; PPAR-beta - antagonists & inhibitors; PPAR-beta - metabolism; transcription factor; transcription factor; cancer; chemoprevention; peroxisome proliferator-activated receptor-β/δ; mechanisms
• ISSN: 1043-2760; 1879-3061
• DOI: 10.1016/j.tem.2015.09.004

The role of the nuclear hormone receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in carcinogenesis is controversial because conflicting studies indicate that it both inhibits and promotes tumorigenesis. In this review, we focus on recent studies on PPARβ/δ including the significance of increased or decreased PPARβ/δ expression in cancers; a range of opposing mechanisms describing how PPARβ/δ agonists, antagonists, and inverse agonists regulate tumorigenesis and/or whether there may be cell context-specific mechanisms; and whether activating or inhibiting PPARβ/δ is feasible for cancer chemoprevention and/or therapy. Research questions that need to be addressed are highlighted to establish whether PPARβ/δ can be effectively targeted for cancer chemoprevention.