Biological Activities of Some Natural Compounds and Their Cytotoxicity Studies against Breast and Prostate Cancer Cell Lines and Anti-COVID19 Studies

• Published in: Journal of Oleo Science Vol. 71; no. 4; pp. 587 - 597
• Main Authors: Liu, Xin, Zhao, Jiangtao, Qiu, Guoqiang, Alahmadi, Tahani Awad, Alharbi, Sulaiman Ali, Wainwright, Milton, Duan, Wei
• Format: Journal Article
• Language: English
• Published: Japan Japan Oil Chemists' Society 01.01.2022; Japan Science and Technology Agency
• Subjects: Antioxidants; Cell Line; COVID-19 - drug therapy; COVID19; Cytotoxicity; enzyme inhibition; Enzymes; Humans; Male; Mathematical analysis; Molecular docking; Molecular Docking Simulation; Oxidizing agents; phenolic compounds; Prostate; Prostate cancer; Prostatic Neoplasms - drug therapy; Proteins; Reductases; RNA polymerase; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Toxicity; phenolic compounds; COVID19; molecular docking; enzyme inhibition; cytotoxicity
• ISSN: 1345-8957; 1347-3352
• DOI: 10.5650/jos.ess21275

In this study, we investigated the inhibition effects of matairesinol, pregnanolone, hamamelitannin, secoisolariciresinol, and secoisolariciresinol diglicoside compounds on HMG-CoA reductase and urease enzymes. We have obtained results for the HMG-CoA reductase enzyme at the millimolar level, and for the urease enzyme at the micromolar level. Molecular docking calculations were made for their biological activities were compared. In docking calculations, proteins of experimentally used enzymes, activities of SARS-CoV-2 virus against RNA-dependent RNA polymerase (RdRp) protein, and anti-oxidant protein were compared. Then, ADME/T calculations were made to use the molecules as drugs. Cytotoxicity potential of these complexes against human breast and prostate cancers demonstrated that these compounds had good cytotoxic effects. There is growing attention to phenolic molecules and their presumed role in avoiding diverse degenerative diseases, such as cardiovascular and cancer diseases.