Lack of Smad or Notch Leads to a Fatal Game of Brain Pericyte Hopscotch

Pericytes surround and stabilize the vast capillary network of the central nervous system. In this issue of Developmental Cell, Li et al. (2011) show that Smad4 and Notch signaling together regulate endothelial expression of an adhesion factor, N-cadherin, which couples pericytes to the endothelial...

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Published inDevelopmental cell Vol. 20; no. 3; pp. 279 - 280
Main Authors Winkler, Ethan A., Bell, Robert D., Zlokovic, Berislav V.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.03.2011
Subjects
Brain
Central nervous system
Endothelial cells
Hemorrhage
N-Cadherin
Neonates
Notch protein
pericytes
Smad protein
Smad4 protein
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Summary:Pericytes surround and stabilize the vast capillary network of the central nervous system. In this issue of Developmental Cell, Li et al. (2011) show that Smad4 and Notch signaling together regulate endothelial expression of an adhesion factor, N-cadherin, which couples pericytes to the endothelial cell wall, thereby preventing neonatal intraventricular hemorrhage.
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ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2011.03.002