Paired CT Measures of Emphysema and Small Airways Disease and Lung Function and Exercise Capacity in Smokers with Radiographic Bronchiectasis

• Published in: Academic radiology Vol. 28; no. 3; p. 370
• Main Authors: Martinez, Carlos H, Okajima, Yuka, Yen, Andrew, Maselli, Diego J, Nardelli, Pietro, Rahaghi, Farbord, Young, Kendra, Kinney, Gregory, Hatt, Charles, Galban, Craig, Washko, George R, Han, MeiLan, Estépar, Raúl San José, Diaz, Alejandro A
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021
• Subjects: Bronchiectasis - diagnostic imaging; Emphysema; Exercise Tolerance; Forced Expiratory Volume; Humans; Lung - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Emphysema - diagnostic imaging; Smokers; Tomography, X-Ray Computed; Bronchiectasis; Six-minute walk test; Computed tomography; Small airway disease; Emphysema
• ISSN: 1878-4046
• DOI: 10.1016/j.acra.2020.02.013

Bronchiectasis (BE) is associated with chronic obstructive pulmonary disease (COPD), but emphysema and small airways disease, main pathologic features of COPD, have been sparsely studied in BE. We aimed to objectively assess those features in smokers with and without radiographic BE and examine its relationships to airflow obstruction and exercise capacity. We measured emphysema and small airways disease on paired inspiratory-expiratory computed tomography (CT) scans with the parametric response map (PRM and PRM ) method in 1184 smokers with and without radiographic BE. PRM and PRM are expressed as the percentage of lung area. Clinical, spirometry, and exercise capacity data were measured with standardized methods. The differences in PRM and PRM between subjects with and without radiographic BE were assessed using multivariable linear regression analysis, and their associations with FEV and six-minute walk test (6MWT) were assessed with generalized linear models. Out of 1184 subjects, 383 (32%) had radiographic BE. PRM but not PRM was higher in subjects with radiographic BE than those without radiographic BE in adjusted models. Subjects with radiographic BE and PRM (defined as ≥5% on paired CTs) had lower FEV (least square mean, 1479 mL vs. 2350 mL p < 0.0001) and 6MWT (372 m vs. 426 m p = 0.0007) than those with radiographic BE alone in adjusted models. Smokers with radiographic BE have an increased burden of emphysema on paired CTs, and those with radiographic BE and emphysema have lower airflow and exercise capacity.