Electrocardiographic manifestations of COVID-19: Effect on cardiac activation and repolarization

• Published in: EClinicalMedicine Vol. 39; p. 101057
• Main Authors: Thakore, Avni, Nguyen, James, Pollack, Simcha, Muehlbauer, Stefan, Chi, Benjamin, Knight, Derek, Mehrotra, Bhoomi, Stern, Joshua, Cao, J. Jane, Lucore, Charles, Levine, Joseph
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2021; Elsevier
• Subjects: Activation; BNP; Cardiac involvement; COVID-19; Electrocardiogram; Mortality; NTPRO BNP; QRS; QT interval; QTc interval; repolarization; Research Paper; SAR-COV-2; Troponin; QT interval; BNP; Mortality; repolarization; Activation; NTPRO BNP; COVID-19; QTc interval; Troponin; QRS; Electrocardiogram; Cardiac involvement; SAR-COV-2
• ISSN: 2589-5370; 2589-5370
• DOI: 10.1016/j.eclinm.2021.101057

Prolonged QT intervals are reported in patients with COVID-19. Additionally, virus particles in heart tissue and abnormal troponin levels have been reported. Consequently, we hypothesize that cardiac electrophysiologic abnormalities may be associated with COVID-19. This is a retrospective study between March 15th, 2020 and May 30th, 2020 of 828 patients with COVID-19 and baseline ECG. Corrected QT (QTc) and QRS intervals were measured from ECGs performed prior to intervention or administration of QT prolonging drugs. QTc and QRS intervals were evaluated as a function of disease severity (patients admitted versus discharged; inpatients admitted to medical unit vs ICU) and cardiac involvement (troponin elevation >0.03 ng/ml, elevated B-natriuretic peptide (BNP) or NT pro-BNP >500 pg/ml). Multivariable analysis was used to test for significance. Odds ratios for predictors of disease severity and mortality were generated. Baseline QTc of inpatients was prolonged compared to patients discharged (450.1±30.2 versus 423.4±21.7  msec, p<0.0001) and relative to a control group of patients with influenza (p=0.006). Inpatients with abnormal cardiac biomarkers had prolonged QTc and QRS compared to those with normal levels (troponin - QTc: 460.9±34.6 versus 445.3±26.6  msec, p<0.0001, QRS: 98.7±24.6 vs 90.5±16.9  msec, p<0.0001; BNP - QTc: 465.9±33.0 versus 446.0±26.2  msec, p<0.0001, QRS: 103.6±25.3 versus 90.6±17.6 msec, p<0.0001). Findings were confirmed with multivariable analysis (all p<0.05). QTc prolongation independently predicted mortality (8.3% increase in mortality for every 10  msec increase in QTc; OR 1.083, CI [1.002, 1.171], p=0.04). QRS and QTc intervals are early markers for COVID-19 disease progression and mortality. ECG, a readily accessible tool, identifies cardiac involvement and may be used to predict disease course. St. Francis Foundation.