Exploration of the Correlation Between GRHL1 Expression and Tumor Microenvironment in Endometrial Cancer and Immunotherapy

belongs to the family of Grainyhead-like (GRHL). Previous studies have shown that dysregulation of growth and survival pathways is associated with the GRHL family of gene cancers. Immunotherapy with checkpoint inhibitors has changed the treatment paradigm for many tumors, including endometrial cance...

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Published inPharmacogenomics and personalized medicine Vol. 17; pp. 91 - 103
Main Authors Guo, Suyang, Bai, Wenqi, Cui, Fengjie, Chen, Xin, Fang, Xiaojing, Shen, Honghong, Gu, Xianhua
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2024
Dove
Dove Medical Press
Subjects
Analysis
B cells
Cancer
Care and treatment
cd8+ t cells
Endometrial cancer
Genes
Genetic aspects
grhl1
Immunohistochemistry
Immunotherapy
Original Research
T cells
tumor microenvironment
China
endometrial cancer
CD8+ T cells
tumor microenvironment
GRHL1
immunotherapy
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Summary:belongs to the family of Grainyhead-like (GRHL). Previous studies have shown that dysregulation of growth and survival pathways is associated with the GRHL family of gene cancers. Immunotherapy with checkpoint inhibitors has changed the treatment paradigm for many tumors, including endometrial cancer (EC). However, the effect of on immunotherapy in EC and its relationship with immune cell infiltration are poorly understood. Differential expression of between EC and normal EC tissues was analyzed by searching the TCGA database, and the results were verified utilizing immunohistochemistry analyses. Next, the relationship between , CD8+ T cells and tumor microenvironment (TME) was also investigated, and the effect of expression on immunotherapy in EC was evaluated. According to the findings, EC tissues had elevated expression levels of relative to normal tissues. Patients with EC who expressed at high levels experienced worse overall survival (OS) and Progression-free survival (PFS) than those whose expression was lower. In addition, expression was negatively correlated with CD8+ T cells, and patients with high expression were less effective in receiving immunotherapy. The expression of was high in EC patients, and high expression of inhibits the proliferation of CD8+ T cells in the tumor microenvironment of EC and affect the efficacy of immunotherapy.
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ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S453061