Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety

Highlights • Women are more vulnerable to the depressogenic effects of inflammation than men. • Stress precipitates the development of mood disorders via neuroimmune alterations. • Sex differences in stress-related neuroinflammation are largely unknown. • Sex-specific neuroimmune effects of stress m...

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 67; pp. 1 - 12
Main Authors Bekhbat, Mandakh, Neigh, Gretchen N
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.01.2018
Subjects
Allergy and Immunology
Animals
Anxiety Disorders - complications
Anxiety Disorders - epidemiology
Anxiety Disorders - immunology
Depressive Disorder - complications
Depressive Disorder - epidemiology
Depressive Disorder - immunology
Encephalitis - complications
Encephalitis - epidemiology
Encephalitis - immunology
Female
Humans
Neuroimmunomodulation
Neuroinflammation
Psychiatry
Sex differences
Sex Factors
Stress
Stress, Psychological - complications
Stress, Psychological - epidemiology
Stress, Psychological - immunology
Sex differences
Neuroinflammation
Female
Stress
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Summary:Highlights • Women are more vulnerable to the depressogenic effects of inflammation than men. • Stress precipitates the development of mood disorders via neuroimmune alterations. • Sex differences in stress-related neuroinflammation are largely unknown. • Sex-specific neuroimmune effects of stress may explain the female bias in depression. • Replication of stress-induced neuroinflammation research in females is necessary.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2017.02.006