Dining in: intracellular bacterial pathogen interplay with autophagy

Highlights • Intracellular bacterial pathogens must confront host cell autophagy to control infection. • A subset of pathogens actively engages autophagy to promote infection and survival. • Secreted bacterial proteins are responsible for many host cell exploitations. • New mechanisms of bacterial i...

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Bibliographic Details
Published inCurrent opinion in microbiology Vol. 29; pp. 9 - 14
Main Authors Winchell, Caylin G, Steele, Shaun, Kawula, Tom, Voth, Daniel E
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2016
Subjects
Autophagy
Bacteria - growth & development
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Proteins - metabolism
Bacterial Secretion Systems - physiology
Coxiella burnetii - metabolism
Coxiella burnetii - pathogenicity
Cytoplasm - microbiology
Eukaryotic Cells - microbiology
Host-Pathogen Interactions
Humans
Lysosomes - microbiology
Lysosomes - physiology
Microbial Viability
Pathology
Phagosomes - microbiology
Signal Transduction
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Summary:Highlights • Intracellular bacterial pathogens must confront host cell autophagy to control infection. • A subset of pathogens actively engages autophagy to promote infection and survival. • Secreted bacterial proteins are responsible for many host cell exploitations. • New mechanisms of bacterial interplay with autophagy have been discovered. • Novel autophagy-related events provide insight into host cell responses and bacterial pathogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2015.09.004