Unintended effects of cranial irradiation on cognitive function

This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the impo...

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Bibliographic Details
Published inToxicologic pathology Vol. 38; no. 1; p. 198
Main Author Raber, Jacob
Format Journal Article
LanguageEnglish
Published United States 01.01.2010
Subjects
Animals
Antineoplastic Agents - adverse effects
Cognition - radiation effects
Cranial Irradiation - adverse effects
Female
Genetic Predisposition to Disease
Humans
Male
Mice
Neurogenesis
Oxidative Stress
Sex Characteristics
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Summary:This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.
ISSN:1533-1601
DOI:10.1177/0192623309352003