Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation

Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue...

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Bibliographic Details
Published inFood & function Vol. 1; no. 6; pp. 3135 - 3141
Main Authors Ávila-Gálvez, M. A, Giménez-Bastida, J. A, González-Sarrías, A, Espín, J. C
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 19.06.2019
Subjects
Conjugation
Ellagic acid
Inflammation
Intestinal microflora
Lipopolysaccharides
Microbiota
Microenvironments
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Summary:Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli. Urolithin A glucuronide is deconjugated to free urolithin A in systemic inflammation.
Bibliography:10.1039/c9fo00298g
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2042-6496
2042-650X
DOI:10.1039/c9fo00298g