Major reduction of NKT cells in patients with severe COVID-19 pneumonia

NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). Acco...

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Published inClinical immunology (Orlando, Fla.) Vol. 222; p. 108630
Main Authors Zingaropoli, Maria Antonella, Perri, Valentina, Pasculli, Patrizia, Cogliati Dezza, Francesco, Nijhawan, Parni, Savelloni, Giulia, La Torre, Giuseppe, D'Agostino, Claudia, Mengoni, Fabio, Lichtner, Miriam, Ciardi, Maria Rosa, Mastroianni, Claudio Maria
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2021
Subjects
Aged
Aged, 80 and over
Antigens, CD - genetics
Antigens, CD - metabolism
CD56bright
CD56dim
COVID-19 - pathology
Female
Flow Cytometry
Full Length
Gene Expression Regulation
Humans
Immunophenotyping analysis
Male
Middle Aged
Natural Killer T-Cells - classification
Natural Killer T-Cells - metabolism
Natural Killer T-Cells - physiology
SARS-CoV-2
CD56dim
SARS-CoV-2
Immunophenotyping analysis
Flow Cytometry
CD56bright
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Summary:NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset. [Display omitted] •High percentages of NK CD57+ cells and CD56dimNK cells in COVID-19 subjects•Low percentages of CD56bright and NKT cells in COVID-19 subjects•Severe COVID-19 pneumonia and NKT cell reduction were independently associated
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ISSN:1521-6616
1521-7035
1521-7035
DOI:10.1016/j.clim.2020.108630