PRIME-IPD SERIES Part 2. Retrieving, checking, and harmonizing data are underappreciated challenges in individual participant data meta-analyses

Data sharing platforms offer some potential to easily access IPD [4], but they may not house all relevant variables, and their use can remove the opportunity to communicate with the original study investigators, which often adds valuable insight. There is also an absence of a standardized data prepa...

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Bibliographic Details
Published inJournal of clinical epidemiology Vol. 136; pp. 221 - 223
Main Authors Levis, Brooke, Hattle, Miriam, Riley, Richard D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2021
Elsevier Limited
Subjects
Coronaviruses
COVID-19
Data Analysis
Data harmonization and checking
Data retrieval
Datasets
Epidemiology
Females
Humans
individual participant data (IPD) meta-analysis
Information sharing
Internal Medicine
Males
Medical research
Meta-analysis
Research Subjects
Statistical methods
Teams
Transparency
Variables
Data harmonization and checking
Transparency
individual participant data (IPD) meta-analysis
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Summary:Data sharing platforms offer some potential to easily access IPD [4], but they may not house all relevant variables, and their use can remove the opportunity to communicate with the original study investigators, which often adds valuable insight. There is also an absence of a standardized data preparation approach, which may assist IPD project teams in planning and executing data preparation tasks, and would help others, such as funders and reviewers, understand the processes involved. [...]variables such as sex may be coded as 1=females/0=males in some studies but 1=males/0=females in others; therefore, caution is needed.2 Replication An important step, where possible, is to replicate each included study's main results, following the study's reported statistical methods. Furthermore, the analysis phase can reveal further (unexpected) data checking issues that need to be resolved. [...]time for analyses must be protected.
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ISSN:0895-4356
1878-5921
1878-5921
DOI:10.1016/j.jclinepi.2021.05.006