The effect of sevoflurane compared to propofol maintenance on post-surgical quality of recovery in patients undergoing an ambulatory gynecological surgery: A prospective, randomized, double-blinded, controlled, clinical trial

• Published in: Journal of clinical anesthesia Vol. 43; pp. 70 - 74
• Main Authors: De Oliveira, Gildasio S., Bialek, Jane, Rodes, Meghan E., Kendall, Mark C., McCarthy, Robert J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017; Elsevier Limited
• Subjects: Analgesics; Anesthesia; Clinical trials; Females; Gynecology; Laparoscopy; Narcotics; Pain; Pain Medicine; Patients; Propofol; Quality; Quality of recovery; Questionnaires; Recovery (Medical); Sevoflurane; Surgery; Sevoflurane; Quality of recovery; Propofol
• ISSN: 0952-8180; 1873-4529; 1873-4529
• DOI: 10.1016/j.jclinane.2017.10.001

The main objective of the current investigation was to evaluate the effect of propofol used as anesthetic maintenance compared to sevoflurane on global post-surgical quality of recovery in female patients undergoing ambulatory gynecological surgery. The study was a prospective randomized double blinded, controlled, clinical trial. Healthy female subjects were randomized to receive propofol or sevoflurane as anesthetic maintenance. The primary outcome was the Quality of Recovery 40 (QOR-40) questionnaire at 24h after surgery. Other data collected included opioid consumption, pain scores and time to hospital discharge. P<0.05 was used to reject the null hypothesis for the primary outcome. Ninety subjects were randomized and sixty seven completed the study. Patient's baseline characteristics and surgical factors were not different between study groups. There was not a clinically significant difference in the global QoR-40 scores between the sevoflurane and the propofol groups, median (IQR) of 175 (163 to 181) and 176 (163 to 184), respectively, P=0.97. There was an inverse relationship (ρ=−0.42) between the opioid consumption in PACU (IV morphine equivalents) and 24h postoperative quality of recovery (P<0.001) and an inverse relationship (ρ=−0.48) between the oral opioid consumption at home (oral morphine equivalents) and 24h postoperative quality of recovery, P<0.001. Our current results do not support the use of total intravenous anesthesia as an efficacious strategy to improve global quality of recovery after ambulatory surgery. Opioid consumption in the PACU is an earlier surrogate that can be utilized to identify ambulatory patients with a high likelihood to develop poor global quality of recovery and who may benefit from more efficacious strategies to improve global quality of recovery. Trial registration: ClinicalTrial.gov; url: http://www.clinicaltrials.gov; registration identified: NCT 01755234. •The use of propofol as maintenance of anesthesia has been suggested to improve recovery after ambulatory surgery when compared to volatile anesthetics.•We did not find evidence to determine that propofol is a better choice to improve quality of recovery when compared to sevoflurane.•Our results suggest that both agents are acceptable as maintenance of anesthesia for ambulatory surgery.