Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: A meta-analysis

• Published in: Atherosclerosis Vol. 254; pp. 193 - 199
• Main Authors: Wang, Ruijuan, Song, Youxin, Yan, Yaqi, Ding, Zhenjiang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2016
• Subjects: Aged; All-cause mortality; Cardiovascular; Cardiovascular Diseases - blood; Cardiovascular Diseases - complications; Cardiovascular Diseases - mortality; Cardiovascular mortality; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - mortality; Female; Humans; Male; Meta-analysis; Middle Aged; Mortality; Observational Studies as Topic; Prospective Studies; Retrospective Studies; Risk Factors; Uric acid; Uric Acid - blood; All-cause mortality; Uric acid; Coronary artery disease; Cardiovascular mortality; Meta-analysis
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2016.10.006

Serum uric acid (SUA) has been recognized as an independent risk factor for mortality in the general population. We performed this meta-analysis to determine whether elevated SUA levels are associated with greater risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease (CAD). The Pubmed and Embase databases were searched up to April 1, 2016 for the longitudinal studies that investigated the association between the elevated SUA and cardiovascular or all-cause mortality risk in people with suspected or definite CAD. Pooled adjusted risk ratio (RR) and corresponding 95% confidence interval (CI) were calculated for the highest vs. the lowest SUA category or each 1 mg/ml SUA rise. Nine studies enrolling 25,229 participants were included in the analyses. The highest vs. lowest SUA category was associated with greater risk of cardiovascular mortality (RR 2.09; 95% CI: 1.45–3.02) and all-cause mortality (RR 1.80; 95% CI: 1.39–2.34) after adjustment for potential confounders in a random effects model. Moreover, each 1 mg/ml SUA rise significantly increased by 12% cardiovascular mortality and by 20% all-cause mortality. Elevated SUA levels are strongly and independently associated with greater risk of cardiovascular and all-cause mortality in people with suspected or definite CAD. •The magnitude of Serum uric acid (SUA) level on cardiovascular and all-cause mortality risk varied across studies.•Subjects with highest SUA level was associated with an 80% increase in all-cause mortality.•Subjects with highest SUA level was associated with a 109% increase in cardiovascular mortality.•Each 1 mg/ml SUA rise increased 12% cardiovascular mortality and 20% all-cause mortality.