Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies

• Published in: Arthritis and rheumatism Vol. 37; no. 6; p. 902
• Main Authors: Kuwana, M, Okano, Y, Kaburaki, J, Tojo, T, Medsger, Jr, T A
• Format: Journal Article
• Language: English
• Published: United States 01.06.1994
• Subjects: Antibodies, Antinuclear - blood; Asian People; Autoimmune Diseases - blood; Autoimmune Diseases - ethnology; Autoimmune Diseases - immunology; Black or African American; Black People; Humans; Japan; Scleroderma, Systemic - blood; Scleroderma, Systemic - ethnology; Scleroderma, Systemic - immunology; United States; White People; United States; Japan
• ISSN: 0004-3591
• DOI: 10.1002/art.1780370619

To determine racial differences in the frequencies of systemic sclerosis (SSc)-related serum antinuclear antibodies (ANA). We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc-related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays. In comparing the 3 racial groups, we found that anti-U1 RNP, anti-RNA polymerase I, II, and III, and anti-U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti-PM-Scl antibody was found exclusively in Caucasians. The production of SSc-related serum ANA is related to immunogenetic background.