Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient

• Published in: Pediatric transplantation Vol. 15; no. 1; pp. E1 - E7
• Main Authors: Narayan, Shoba, Tsai, Eileen W., Zhang, Qiuheng, Wallace, William D., Reed, Elaine F., Ettenger, Robert B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011
• Subjects: Adolescent; Alleles; Antibodies; antibody‐mediated rejection; anti‐MICA antibody; Biopsy; Branchio-Oto-Renal Syndrome - immunology; Branchio-Oto-Renal Syndrome - therapy; Case reports; Classification; Donors; donor‐specific anti‐MICA antibody; Female; Graft Rejection; highly sensitized patient; Histocompatibility antigen HLA; Histocompatibility Testing; HLA Antigens - chemistry; Humans; Kidney transplantation; Kidney Transplantation - methods; Lymphocytes; MICA protein; non‐HLA antibody; Pediatrics; Pediatrics - methods; Retinoblastoma protein; Transplantation, Homologous; Treatment Outcome
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/j.1399-3046.2010.01407.x

Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient.
Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S. :  Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients.