Multiple Myeloma in a Young Adult with Renal Involvement

• Published in: Clinical case reports Vol. 11; no. 2; pp. e6986 - n/a
• Main Authors: Hajji, Meriam, Barbouch, Samia, Goucha, Rim, Abderrahim, Ezzeddine
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2023; John Wiley and Sons Inc; Wiley
• Subjects: Age; Amyloidosis; Anemia; Biopsy; Case Report; Case reports; cast nephropathy; Creatinine; early‐onset multiple myeloma; Hypercalcemia; Informed consent; Kidney diseases; Medical prognosis; Multiple myeloma; Patients; prognosis; Proteins; renal biopsy; survival; treatment response; Urine; cast nephropathy; early‐onset multiple myeloma; prognosis; treatment response; renal biopsy; survival
• ISSN: 2050-0904; 2050-0904
• DOI: 10.1002/ccr3.6986

Multiple myeloma (MM) results from malignant plasma cell disorder. It represents approximately 10% of hematological malignancies and it is typically diagnosed in the elderly with a median age of 70 years and has a steep increase in incidence with advancing age. N Engl J Med. 2004, 1860; Clin Interv Aging. 2020, 619. The incidence of MM has been increasing over time, mostly due to population aging. Mayo Clin Proc. 2010, 225 However, certain MMs are diagnosed at young age even under 40 years old (2%). Leuk Lymphoma. 1998, 493; Blood. 2010, 5501. We report a case of a MM in a thirty‐four‐year‐old woman whose circumstance of discovery was acute kidney failure. (A)Trichrome stain: Intratubular polychromatophilic cylinder with cellular reaction all around (×200). (B) Trichrome stain: Presence of giant cells (×400). (C) Trichrome stain: Optically normal glomeruli (×200). (D) Direct Immunofluorescence: Absence of Ig deposits but presence of lambda on tubular basement membranes and cylinders.