F4/80 and the related adhesion‐GPCRs

The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805–815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF‐TM7 family of leukocyte plasma membrane heptahe...

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Published inEuropean journal of immunology Vol. 41; no. 9; pp. 2472 - 2476
Main Authors Gordon, Siamon, Hamann, Jörg, Lin, Hsi‐Hsien, Stacey, Martin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 01.09.2011
Wiley Subscription Services, Inc
Subjects
Adhesion‐GPCRs
Animals
Antigens, CD - immunology
Antigens, Differentiation - immunology
Antigens, Differentiation - metabolism
Biomarkers - metabolism
Cell Adhesion - immunology
Cell Differentiation
EGF‐TM7 family
Humans
Macrophages
Macrophages - immunology
Mice
Monocytes - immunology
Receptors, G-Protein-Coupled - immunology
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Summary:The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805–815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF‐TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF‐TM7 family, as part of a larger family of tissue adhesion‐GPCRs.
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ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201141715