Detection of thiopentone-reactive IgE antibodies following anaphylactoid reactions during anaesthesia

A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone-reactive IgE antibodies were found in the sera of two patients who had experienced life-threatening anaphylactoid reactions following administration of the drug...

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Bibliographic Details
Published inClinical allergy Vol. 16; no. 5; pp. 493 - 498
Main Authors HARLE, D. G, BALDO, B. A, SMAL, M. A, WAJON, P, FISHER, M. M
Format Journal Article
LanguageEnglish
Published Oxford Blackwell 01.09.1986
Subjects
Anaphylaxis - etiology
Anaphylaxis - immunology
Anesthesia
Anesthesia - adverse effects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Drug Hypersensitivity - etiology
Drug Hypersensitivity - immunology
Female
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Humans
Immunoglobulin E - analysis
Immunoglobulin E - immunology
Medical sciences
Middle Aged
Radioimmunoassay - methods
Thiopental - adverse effects
Thiopental - immunology
Human
General anesthesia
General anesthetic
Anaphylactoid reaction
IgE
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Summary:A radioimmunoassay was developed to detect IgE antibodies to the anaesthetic induction agent thiopentone. Significant levels of thiopentone-reactive IgE antibodies were found in the sera of two patients who had experienced life-threatening anaphylactoid reactions following administration of the drug. Inhibition experiments revealed that cross-reactivity occurs between the drug-reactive IgE antibodies and four barbiturate analogues pentobarbitone, phenobarbitone, barbitone and methohexital. The assay should supplement skin testing for the detection of patients with potentially lethal sensitivity to thiopentone.
ISSN:0009-9090
DOI:10.1111/j.1365-2222.1986.tb01984.x