The prognostic analysis of 123 postpartum choriocarcinoma cases

• Published in: International journal of gynecological cancer Vol. 18; no. 5; pp. 1097 - 1101
• Main Authors: Ma, Y, Xiang, Y, Wan, X R, Chen, Y, Feng, F Z, Lei, C Z, Yang, X Y
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.09.2008
• Subjects: Adult; Chemotherapy; Choriocarcinoma - drug therapy; Choriocarcinoma - epidemiology; Choriocarcinoma - pathology; Choriocarcinoma - surgery; Female; Humans; Middle Aged; Postpartum Period - physiology; Prognosis; Uterine Neoplasms - drug therapy; Uterine Neoplasms - epidemiology; Uterine Neoplasms - pathology; Uterine Neoplasms - surgery
• ISSN: 1048-891X; 1525-1438
• DOI: 10.1111/j.1525-1438.2007.01132.x

A retrospective analysis of 123 postpartum choriocarcinoma cases treated at the Peking Union Medical College Hospital between December 1985 and December 2006 was performed. All the patients with postpartum choriocarcinoma received chemotherapy, combined with comprehensive therapy. The total number of chemotherapy cycles was 1041 (8.5 for every patient on average). The complete remission (CR) was achieved in 108 patients (87.8%), whereas five patients had partial remission and ten died. Of the 26 patients who became resistant to 5-fluorouracil combined chemotherapy, 18 achieved CR. Of the four cases who had recurrence, three achieved CR. The patients were divided into high- and low-risk groups, based on the new FIGO 2000 risk factor scoring system. Seventy-five patients were in high-risk group, with a score of 7 or more. Among them, 62 achieved CR (82.7%). The remaining 48 patients were in the low-risk group, with a score of 6 or less, among whom 46 patients achieved CR (95.8%). There is a significant difference in CR rate between the two groups. Based on the FIGO staging and scoring system, 24 patients were diagnosed as FIGO stage I, 9 stage II, 66 stage III, and 24 stage IV. The rate of CR was 100%, 100%, 91%, and 62.5%, respectively. Our experience shows that prognosis of postpartum choriocarcinoma is good when multiagent systemic chemotherapy is applied. Shortened time interval between the antecedent pregnancy and the treatment will lead to better prognosis.