Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

• Published in: Clinical and translational medicine Vol. 12; no. 11; pp. e1101 - n/a
• Main Authors: Sun, He‐Fen, Li, Liang‐Dong, Lao, I‐Weng, Li, Xuan, Xu, Bao‐Jin, Cao, Yi‐Qun, Jin, Wei
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2022; John Wiley and Sons Inc; Wiley
• Subjects: Brain cancer; brain metastasis; Brain Neoplasms - genetics; Brain Neoplasms - pathology; CD8-Positive T-Lymphocytes - pathology; Cells; Clinical medicine; Communication; Endothelial Cells - pathology; Gene expression; Genomes; Glioma; Glioma - genetics; Humans; Immunotherapy; Kinases; lung adenocarcinoma; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Mann-Whitney U test; Metastasis; Mutation; programmed cell death 1 ligand 1 (PDL1); Reactive oxygen species; Sequence Analysis, RNA; single‐cell RNA sequencing; Standard scores; Survival analysis; Tumor Microenvironment - genetics; Tumors; tumour microenvironment; single-cell RNA sequencing; glioma; brain metastasis; tumour microenvironment; programmed cell death 1 ligand 1 (PDL1); lung adenocarcinoma

Background Brain malignancies encompass gliomas and brain metastases originating from extracranial tumours including lung cancer. Approximately 50% of patients with lung adenocarcinoma (LUAD) will eventually develop brain metastases. However, the specific characteristics of gliomas and lung‐to‐brain...