Epithelial cell translocation: New insights into mechanisms of tumor initiation

• Published in: BioEssays Vol. 35; no. 2; pp. 80 - 83
• Main Author: Leung, Cheuk T.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.02.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Animals; Cell Communication; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Clone Cells; Drosophila; Epithelial Cells - metabolism; Epithelial Cells - pathology; epithelial tissue; Gene Expression; Genetic Markers; Humans; Mutation; organotypic culture; Signal Transduction; Tissue Culture Techniques; tissue homeostasis; tumor initiation; tumorigenesis

A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of t...