Epithelial cell translocation: New insights into mechanisms of tumor initiation

A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of t...

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Bibliographic Details
Published inBioEssays Vol. 35; no. 2; pp. 80 - 83
Main Author Leung, Cheuk T.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.02.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Animals
Cell Communication
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Clone Cells
Drosophila
Epithelial Cells - metabolism
Epithelial Cells - pathology
epithelial tissue
Gene Expression
Genetic Markers
Humans
Mutation
organotypic culture
Signal Transduction
Tissue Culture Techniques
tissue homeostasis
tumor initiation
tumorigenesis
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Summary:A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.
Bibliography:ark:/67375/WNG-25H7PS7K-Z
ArticleID:BIES201200151
istex:99D27D4D82664814355BB47F1C9B403B0E954C0C
Current address: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.201200151