Epithelial cell translocation: New insights into mechanisms of tumor initiation

A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of t...

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Published inBioEssays Vol. 35; no. 2; pp. 80 - 83
Main Author Leung, Cheuk T.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.02.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Animals
Cell Communication
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Clone Cells
Drosophila
Epithelial Cells - metabolism
Epithelial Cells - pathology
epithelial tissue
Gene Expression
Genetic Markers
Humans
Mutation
organotypic culture
Signal Transduction
Tissue Culture Techniques
tissue homeostasis
tumor initiation
tumorigenesis
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Abstract A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.
AbstractList A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This epithelial cell translocation process exerts a selective pressure on early mutant cells to survive and grow in new microenvironment outside of their native niches.
Author Leung, Cheuk T.
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CitedBy_id crossref_primary_10_1016_j_cytogfr_2015_06_001
crossref_primary_10_1016_j_oraloncology_2014_06_012
Cites_doi 10.1002/jcp.20639
10.1016/S0092-8674(04)00262-4
10.1091/mbc.E11-05-0469
10.1038/nature10984
10.1038/309552a0
10.1038/nature10826
10.1097/01.pap.0000184177.65919.5e
10.1016/j.cell.2007.03.054
10.1126/science.1104784
10.1038/ncb1853
10.1016/j.cell.2009.10.027
10.1083/jcb.200903079
10.1016/S0092-8674(04)00214-4
10.1242/jcs.057976
10.1016/S0960-9822(01)00587-5
10.1371/journal.pbio.1000422
10.1038/nrc1695
10.1158/0008-5472.CAN-10-3782
10.1126/science.1104751
10.1126/science.2996144
10.1073/pnas.93.24.14025
10.1038/nature10999
10.1016/j.devcel.2010.05.010
10.1126/science.959840
10.1016/S0092-8674(02)01001-2
10.1242/jcs.085803
10.1073/pnas.0704677104
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References Debnath J, Brugge JS. 2005. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675- 88.
Marinari E, Mehonic A, Curran S, Gale J, et al. 2012. Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature 484: 542- 5.
Jonason AS, Kunala S, Price GJ, Restifo RJ, et al. 1996. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci USA 93: 14025- 9.
Rosenblatt J, Raff MC, Cramer LP. 2001. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol 11: 1847- 57.
Rhiner C, Lopez-Gay JM, Soldini D, Casas-Tinto S, et al. 2010. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell 18: 985- 98.
Holst CR, Nuovo GJ, Esteller M, Chew K, et al. 2003. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 63: 1596- 601.
Dolberg DS, Hollingsworth R, Hertle M, Bissell MJ. 1985. Wounding and its role in RSV-mediated tumor formation. Science 230: 676- 8.
Levental KR, Yu H, Kass L, Lakins JN, et al. 2009. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139: 891- 906.
Marshall TW, Lloyd IE, Delalande JM, Nathke I, et al. 2011. The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. Mol Biol Cell 22: 3962- 70.
Norman M, Wisniewska KA, Lawrenson K, Garcia-Miranda P, et al. 2012. Loss of Scribble causes cell competition in mammalian cells. J Cell Sci 125: 59- 66.
Tamori Y, Bialucha CU, Tian AG, Kajita M, et al. 2010. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol 8: e1000422.
Simpson DR, Yu M, Zheng S, Zhao Z, et al. 2011. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res 71: 3822- 30.
Shen J, Dahmann C. 2005. Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia. Science 307: 1789- 90.
Gibson MC, Perrimon N. 2005. Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307: 1785- 9.
de la Cova C, Abril M, Bellosta P, Gallant P, et al. 2004. Drosophila myc regulates organ size by inducing cell competition. Cell 117: 107- 16.
Slattum G, McGee KM, Rosenblatt J. 2009. P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. J Cell Biol 186: 693- 702.
Moreno E, Basler K. 2004. dMyc transforms cells into super-competitors. Cell 117: 117- 29.
Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194: 23- 8.
Hogan C, Dupre-Crochet S, Norman M, Kajita M, et al. 2009. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 11: 460- 7.
Partanen JI, Nieminen AI, Makela TP, Klefstrom J. 2007. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 104: 14694- 9.
Kajita M, Hogan C, Harris AR, Dupre-Crochet S, et al. 2010. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 123: 171- 80.
Nofech-Mozes S, Spayne J, Rakovitch E, Hanna W. 2005. Prognostic and predictive molecular markers in DCIS: a review. Adv Anat Pathol 12: 256- 64.
Debnath J, Mills KR, Collins NL, Reginato MJ, et al. 2002. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111: 29- 40.
Li W, Baker NE. 2007. Engulfment is required for cell competition. Cell 129: 1215- 25.
Leung CT, Brugge JS. 2012. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature 482: 410- 3.
Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, et al. 2012. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature 484: 546- 9.
Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, et al. 2006. The ultrastructure of MCF-10A acini. J Cell Physiol 208: 141- 8.
Dolberg DS, Bissell MJ. 1984. Inability of Rous sarcoma virus to cause sarcomas in the avian embryo. Nature 309: 552- 6.
2007; 104
2012; 482
2007; 129
2012; 484
2010; 18
2002; 111
2010; 123
1984; 309
1996; 93
2012; 125
2009; 139
2009; 11
2006; 208
1976; 194
2011; 71
2005; 5
2005; 307
2011; 22
2009; 186
2001; 11
2003; 63
2004; 117
1985; 230
2005; 12
2010; 8
2996144 - Science. 1985 Nov 8;230(4726):676-8
17574031 - Cell. 2007 Jun 15;129(6):1215-25
20026643 - J Cell Sci. 2010 Jan 15;123(Pt 2):171-80
15066287 - Cell. 2004 Apr 2;117(1):117-29
12372298 - Cell. 2002 Oct 4;111(1):29-40
17766436 - Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14694-9
16210921 - Adv Anat Pathol. 2005 Sep;12(5):256-64
15774762 - Science. 2005 Mar 18;307(5716):1785-9
20627080 - Dev Cell. 2010 Jun 15;18(6):985-98
20644714 - PLoS Biol. 2010;8(7):e1000422
15066286 - Cell. 2004 Apr 2;117(1):107-16
16148884 - Nat Rev Cancer. 2005 Sep;5(9):675-88
15774763 - Science. 2005 Mar 18;307(5716):1789-90
21900494 - Mol Biol Cell. 2011 Nov;22(21):3962-70
8943054 - Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025-9
11728307 - Curr Biol. 2001 Nov 27;11(23):1847-57
22504183 - Nature. 2012 Apr 26;484(7395):546-9
19287376 - Nat Cell Biol. 2009 Apr;11(4):460-7
12670910 - Cancer Res. 2003 Apr 1;63(7):1596-601
19931152 - Cell. 2009 Nov 25;139(5):891-906
21610111 - Cancer Res. 2011 Jun 1;71(11):3822-30
22504180 - Nature. 2012 Apr 26;484(7395):542-5
959840 - Science. 1976 Oct 1;194(4260):23-8
16607610 - J Cell Physiol. 2006 Jul;208(1):141-8
19720875 - J Cell Biol. 2009 Sep 7;186(5):693-702
22250205 - J Cell Sci. 2012 Jan 1;125(Pt 1):59-66
6203040 - Nature. 1984 Jun 7-13;309(5968):552-6
22318515 - Nature. 2012 Feb 16;482(7385):410-3
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e_1_2_11_3_2
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References_xml – volume: 125
  start-page: 59
  year: 2012
  end-page: 66
  article-title: Loss of Scribble causes cell competition in mammalian cells
  publication-title: J Cell Sci
– volume: 482
  start-page: 410
  year: 2012
  end-page: 3
  article-title: Outgrowth of single oncogene‐expressing cells from suppressive epithelial environments
  publication-title: Nature
– volume: 484
  start-page: 546
  year: 2012
  end-page: 9
  article-title: Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
  publication-title: Nature
– volume: 22
  start-page: 3962
  year: 2011
  end-page: 70
  article-title: The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium
  publication-title: Mol Biol Cell
– volume: 11
  start-page: 460
  year: 2009
  end-page: 7
  article-title: Characterization of the interface between normal and transformed epithelial cells
  publication-title: Nat Cell Biol
– volume: 194
  start-page: 23
  year: 1976
  end-page: 8
  article-title: The clonal evolution of tumor cell populations
  publication-title: Science
– volume: 63
  start-page: 1596
  year: 2003
  end-page: 601
  article-title: Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
  publication-title: Cancer Res
– volume: 139
  start-page: 891
  year: 2009
  end-page: 906
  article-title: Matrix crosslinking forces tumor progression by enhancing integrin signaling
  publication-title: Cell
– volume: 208
  start-page: 141
  year: 2006
  end-page: 8
  article-title: The ultrastructure of MCF‐10A acini
  publication-title: J Cell Physiol
– volume: 129
  start-page: 1215
  year: 2007
  end-page: 25
  article-title: Engulfment is required for cell competition
  publication-title: Cell
– volume: 111
  start-page: 29
  year: 2002
  end-page: 40
  article-title: The role of apoptosis in creating and maintaining luminal space within normal and oncogene‐expressing mammary acini
  publication-title: Cell
– volume: 18
  start-page: 985
  year: 2010
  end-page: 98
  article-title: Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in
  publication-title: Dev Cell
– volume: 123
  start-page: 171
  year: 2010
  end-page: 80
  article-title: Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src‐transformed cells
  publication-title: J Cell Sci
– volume: 71
  start-page: 3822
  year: 2011
  end-page: 30
  article-title: Epithelial cell organization suppresses Myc function by attenuating Myc expression
  publication-title: Cancer Res
– volume: 307
  start-page: 1789
  year: 2005
  end-page: 90
  article-title: Extrusion of cells with inappropriate Dpp signaling from wing disc epithelia
  publication-title: Science
– volume: 117
  start-page: 107
  year: 2004
  end-page: 16
  article-title: myc regulates organ size by inducing cell competition
  publication-title: Cell
– volume: 12
  start-page: 256
  year: 2005
  end-page: 64
  article-title: Prognostic and predictive molecular markers in DCIS: a review
  publication-title: Adv Anat Pathol
– volume: 93
  start-page: 14025
  year: 1996
  end-page: 9
  article-title: Frequent clones of p53‐mutated keratinocytes in normal human skin
  publication-title: Proc Natl Acad Sci USA
– volume: 309
  start-page: 552
  year: 1984
  end-page: 6
  article-title: Inability of Rous sarcoma virus to cause sarcomas in the avian embryo
  publication-title: Nature
– volume: 8
  start-page: e1000422
  year: 2010
  article-title: Involvement of Lgl and Mahjong/VprBP in cell competition
  publication-title: PLoS Biol
– volume: 5
  start-page: 675
  year: 2005
  end-page: 88
  article-title: Modelling glandular epithelial cancers in three‐dimensional cultures
  publication-title: Nat Rev Cancer
– volume: 11
  start-page: 1847
  year: 2001
  end-page: 57
  article-title: An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin‐ and myosin‐dependent mechanism
  publication-title: Curr Biol
– volume: 484
  start-page: 542
  year: 2012
  end-page: 5
  article-title: Live‐cell delamination counterbalances epithelial growth to limit tissue overcrowding
  publication-title: Nature
– volume: 104
  start-page: 14694
  year: 2007
  end-page: 9
  article-title: Suppression of oncogenic properties of c‐Myc by LKB1‐controlled epithelial organization
  publication-title: Proc Natl Acad Sci USA
– volume: 186
  start-page: 693
  year: 2009
  end-page: 702
  article-title: P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
  publication-title: J Cell Biol
– volume: 230
  start-page: 676
  year: 1985
  end-page: 8
  article-title: Wounding and its role in RSV‐mediated tumor formation
  publication-title: Science
– volume: 307
  start-page: 1785
  year: 2005
  end-page: 9
  article-title: Extrusion and death of DPP/BMP‐compromised epithelial cells in the developing wing
  publication-title: Science
– volume: 117
  start-page: 117
  year: 2004
  end-page: 29
  article-title: dMyc transforms cells into super‐competitors
  publication-title: Cell
– ident: e_1_2_11_20_2
  doi: 10.1002/jcp.20639
– ident: e_1_2_11_11_2
  doi: 10.1016/S0092-8674(04)00262-4
– ident: e_1_2_11_26_2
  doi: 10.1091/mbc.E11-05-0469
– ident: e_1_2_11_23_2
  doi: 10.1038/nature10984
– ident: e_1_2_11_3_2
  doi: 10.1038/309552a0
– ident: e_1_2_11_16_2
  doi: 10.1038/nature10826
– volume: 63
  start-page: 1596
  year: 2003
  ident: e_1_2_11_5_2
  article-title: Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
  publication-title: Cancer Res
  contributor:
    fullname: Holst CR
– ident: e_1_2_11_21_2
  doi: 10.1097/01.pap.0000184177.65919.5e
– ident: e_1_2_11_8_2
  doi: 10.1016/j.cell.2007.03.054
– ident: e_1_2_11_9_2
  doi: 10.1126/science.1104784
– ident: e_1_2_11_15_2
  doi: 10.1038/ncb1853
– ident: e_1_2_11_17_2
  doi: 10.1016/j.cell.2009.10.027
– ident: e_1_2_11_27_2
  doi: 10.1083/jcb.200903079
– ident: e_1_2_11_12_2
  doi: 10.1016/S0092-8674(04)00214-4
– ident: e_1_2_11_24_2
  doi: 10.1242/jcs.057976
– ident: e_1_2_11_25_2
  doi: 10.1016/S0960-9822(01)00587-5
– ident: e_1_2_11_14_2
  doi: 10.1371/journal.pbio.1000422
– ident: e_1_2_11_18_2
  doi: 10.1038/nrc1695
– ident: e_1_2_11_29_2
  doi: 10.1158/0008-5472.CAN-10-3782
– ident: e_1_2_11_10_2
  doi: 10.1126/science.1104751
– ident: e_1_2_11_4_2
  doi: 10.1126/science.2996144
– ident: e_1_2_11_6_2
  doi: 10.1073/pnas.93.24.14025
– ident: e_1_2_11_22_2
  doi: 10.1038/nature10999
– ident: e_1_2_11_7_2
  doi: 10.1016/j.devcel.2010.05.010
– ident: e_1_2_11_2_2
  doi: 10.1126/science.959840
– ident: e_1_2_11_19_2
  doi: 10.1016/S0092-8674(02)01001-2
– ident: e_1_2_11_13_2
  doi: 10.1242/jcs.085803
– ident: e_1_2_11_28_2
  doi: 10.1073/pnas.0704677104
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Snippet A cell translocation mechanism displaces sporadic mutant cells from normal, suppressive epithelial environment during early steps of tumor initiation. This...
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SubjectTerms Animals
Cell Communication
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Clone Cells
Drosophila
Epithelial Cells - metabolism
Epithelial Cells - pathology
epithelial tissue
Gene Expression
Genetic Markers
Humans
Mutation
organotypic culture
Signal Transduction
Tissue Culture Techniques
tissue homeostasis
tumor initiation
tumorigenesis
Title Epithelial cell translocation: New insights into mechanisms of tumor initiation
URI https://api.istex.fr/ark:/67375/WNG-25H7PS7K-Z/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbies.201200151
https://www.ncbi.nlm.nih.gov/pubmed/23255249
https://www.proquest.com/docview/1528530012
https://pubmed.ncbi.nlm.nih.gov/PMC3732789
Volume 35
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