Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer

Highlights • p16 IHC has a 92% concordance with high risk HPV oropharyngeal squamous cancer. • ROCHE linear array test identifies additional high risk HPV cancers that are p16 positive. • HPV16 accounts for 92% of HR HPV oropharyngeal cancer. • HPV racial disparity in incidence and survival in Black...

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Bibliographic Details
Published inOral oncology Vol. 51; no. 9; pp. 862 - 869
Main Authors Liu, Sandy Z, Zandberg, Dan P, Schumaker, Lisa M, Papadimitriou, John C, Cullen, Kevin J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2015
Subjects
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - genetics
Case-Control Studies
Female
Genotyping Techniques
Hematology, Oncology and Palliative Medicine
HPV p16 linear array
Human papillomavirus 16 - genetics
Humans
Male
Middle Aged
Oropharyngeal Neoplasms - genetics
Oropharyngeal squamous cell carcinoma
Otolaryngology
Polymerase Chain Reaction
Prognosis
Retrospective Studies
Sensitivity and Specificity
Survival Analysis
Oropharyngeal squamous cell carcinoma
HPV p16 linear array
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Summary:Highlights • p16 IHC has a 92% concordance with high risk HPV oropharyngeal squamous cancer. • ROCHE linear array test identifies additional high risk HPV cancers that are p16 positive. • HPV16 accounts for 92% of HR HPV oropharyngeal cancer. • HPV racial disparity in incidence and survival in Blacks and Whites. • Overall survival by HPV and p16 status.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.06.014